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We use primarily X-ray crystallography in conjunction with other biophysical and biochemical methods to elucidate the protein-protein interactions involved in the intracellular signaling of cell survival and cell death in response to extracelluar signals.

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

Science 304: 448-452 (2004).

Distinct molecular mechanism for initiating TRAF6 signalling

Nature 418: 443-447 (2002).

DNA binding is required for the apoptogenic action of apoptosis inducing factor

Nature Structural Biology 9: 680-684 (2002).

Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex

Nature 410: 494-497 (2001).

Structural Basis of Caspase Inhibition by XIAP: Differential Roles of the Linker versus the BIR Domain

Cell 104: 781-790 (2001).

A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction

Cell 101: 777-787 (2000).

Structural Basis for Self association and Receptor Recognition of Human TRAF2

Nature 398: 533-538 (1999).

The Structural Basis for the Recognition of Diverse Receptor Sequences by TRAF2

Molecular Cell 4: 321-330 (1999).