Weill Cornell Medicine Care Discover Teach
Weill Cornell Medicine — Pediatric Critical Care Medicine

Creatinine Clearance — Measured

All calculations should be independently verified prior to clinical use. These calculators are intended to supplement, not replace, clinical judgment.

Calculate creatinine clearance (CrCl) from a timed urine collection. Optionally enter weight and height to compute BSA-corrected CrCl, normalised to 1.73 m² (the standard adult body surface area).

hr
mL
mg/dL
mg/dL

For BSA-corrected CrCl, also enter weight and height:

mL/min
mL/min/1.73 m²

Creatinine clearance is calculated from a timed urine collection as follows, where Tmin is the collection time converted to minutes:

CrCl = UCr × UVol ÷ ( PCr × Tmin )

In pediatrics, CrCl is generally corrected to a body surface area of 1.73 m² (the standard adult BSA) to allow comparison across patients of different sizes. BSA is calculated using the DuBois & DuBois formula (see Body Surface Area):

Corrected CrCl = CrCl × 1.73 ÷ BSA

Reference ranges for an uncorrected CrCl are 90–139 mL/min for adult males and 80–125 mL/min for adult females. Many medications require dose adjustment when CrCl falls below 50 mL/min. CrCl typically overestimates actual GFR by 10–20% due to active tubular secretion of creatinine.

For estimated CrCl from serum creatinine alone (without urine collection), see the Schwartz and Schwartz Revised calculators.

References

  1. Levey AS, Perrone RD, Madias NE. Serum creatinine and renal function. Annu Rev Med. 1988;39:465–490.
  2. DuBois D, DuBois EF. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med. 1916;17(6):863–871.
  3. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31–41.