Education:

Boston University Boston University
  • Degree: Master of Science in Biomedical Engineering, 1993
  • M.S. thesis: Linear and nonlinear modeling of heart rate variability
The Pennsylvania State University
  • Degree: Bachelor of Science in Electrical Engineering, 1991
  • B.S. Honors thesis: Linear variable differential transformer theory and position control application

Academic Positions:

Primary appointment:

  • Associate Professor: Department of Medicine (Cardiology), Cornell University - Weill Medical College, 2005-

Appointments:

Research Support:

Active:

  1. National Institutes of Health, National Center for Research Resources (#R01RR020115), "Real-time control system for biological experiments", July 2004 - June 2008, Principal Investigator.
  2. National Institutes of Health, Bioengineering Research Partnership (#R01HL073644), "MEMS sensors for arrhythmia detection and intervention", September 2004 - August 2009, co-Principal Investigator (Principal Investigator: Robert Gilmour).
  3. National Science Foundation - Directorate for Mathematical and Physical Sciences (#PHY-0513389), "Spatiotemporal control of cardiac electrical dynamics," August 2005 - July 2008, Principal Investigator.
Completed:

  1. Whitaker Foundation Biomedical Engineering Research Grant (#RG-02-0369), "Endocardial detection and termination of repolarization alternans to prevent tachyarrhythmia initiation", December 2002 - November 2005, Principal Investigator.
  2. National Science Foundation - Directorate for Biological Sciences (#DBI-0352418; renewal of #DBI-0096596), "Integrating and Extending Three Open-Source Real-Time Experiment Control Systems," May 2004 - April 2006, Principal Investigator. Award was relinquished 6/25/04 as required (due to overlap) for acceptance of NIH R01RR020115.
  3. Medtronic CRM External Research Program, "Detection of repolarization alternans preceding ventricular fibrillation," July 2003 - June 2004, Principal Investigator.
  4. American Heart Association Scientist Development Grant - National Center (#0030028N): "Adaptive nonlinear dynamical arrhythmia control," January 2000 - December 2003, Principal Investigator.
  5. National Science Foundation - Directorate for Biological Sciences (DBI-0096596): "Development of an open-source real-time experiment interface system," April 2001 - March 2003, Principal Investigator.
  6. New York State Office of Science, Technology, and Academic Research grant to the Cornell Alliance for Nanomedical Technologies (#NYS-U35-8082355120; Carl Batt, PI). Project: "A wireless cardiac monitoring system," July 2001 - June 2003, co-Principal Investigator (Principal Investigator: Carl Batt).

Peer Reviewed Articles:

  1. Krogh-Madsen T and Christini DJ, "Resetting and termination of reentry in a loop-and-tail cardiac model," Physical Review E, 77:011916-1 -- 011916-5 (2008).
  2. Gordon E, Panaghie G, Deng L, Bee KJ, Roepke TK, Krogh-Madsen T, Christini DJ, Ostrer H, Basson CT, Chung W, and Abbott GW, "A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance," Cardiovascular Research, 77:98-106 (2008).
  3. Jordan PN and Christini DJ, "Characterizing the contribution of voltage- and calcium-dependent coupling to action potential stability: Implications for repolarization alternans," American Journal of Physiology, 293, H2109-H2118 (2007). (Also see Editorial Focus by Z. Qu and JN Weiss.)
  4. Iravanian S and Christini DJ, "Optical mapping system with real-time control capability," American Journal of Physiology, 293, H2605-H2611 (2007).
  5. Gong Y, Xie F, Stein KM, Garfinkel A, Culianu CA, Lerman BB, and Christini DJ, "General mechanism underlying initiation of paroxysmal atrial flutter/atrial fibrillation by ectopic foci - A simulation study," Circulation, 115:2094-2102 (2007). Online Supplement (14MB zip).
  6. Krogh-Madsen T and Christini DJ, "APD dispersion and alternans in simulated heterogeneous cardiac tissue with a structural barrier," Biophysical Journal, 92:1138-1149 (2007).
  7. Christini DJ, Riccio ML, Culianu CA, Fox JJ, Karma A, and Gilmour RF Jr., "Control of electrical alternans in canine cardiac Purkinje fibers," Physical Review Letters, 96:104101-1 -- 104101-4 (2006).
  8. Jordan PN and Christini DJ, "Action potential morphology influences intracellular calcium handling stability and the occurrence of alternans," Biophysical Journal, 90:672-680 (2006).
  9. Maybhate A, Hao SC, Iwai S, Lee JU, Guttigoli AB, Stein KM, Lerman BB, and Christini DJ, "Detection of repolarization alternans with an implantable cardioverter defibrillator lead in a porcine model," IEEE Transactions on Biomedical Engineering, 52:1188-1194 (2005).
  10. Gong Y and Christini DJ, "Functional reentrant waves propagate outwardly in cardiac tissue," Physics Letters A 331:209-216 (2004).
  11. Jordan PN and Christini DJ, "Adaptive diastolic interval control of cardiac action potential duration alternans," Journal of Cardiovascular Electrophysiology 15:1177-1185 (2004). (Also see Editorial comment by Z. Qu.)
  12. Markowitz SM, Christini DJ, Stein KM, Mittal S, Iwai S, Slotwiner DJ, and Lerman BB, "Time course and predictors of autonomic dysfunction after ablation of the slow atrioventricular nodal pathway," Pacing and Clinical Electrophysiology 27:1638-1643 (2004).
  13. Jordan PN and Christini DJ, "Determining the effects of memory and action potential duration alternans on cardiac restitution using a constant-memory restitution protocol," Physiological Measurement 25:1013-1024 (2004).
  14. Hao SC, Christini DJ, Stein KM, Jordan PN, Iwai S, Bramwell O, Markowitz SM, Mittal S, and Lerman BB, "Effect of beta adrenergic blockade on dynamic electrical restitution in vivo," American Journal of Physiology 287:H390-H394 (2004).
  15. Gong Y and Christini DJ, "Antispiral waves in reaction-diffusion systems," Physical Review Letters, 90:088302-1 -- 088302-4 (2003).
  16. Christini DJ, Stein KM, Hao SC, Markowitz SM, Mittal S, Slotwiner DJ, Iwai S, Das MK, and Lerman BB, "Endocardial detection of repolarization alternans," IEEE Transactions on Biomedical Engineering, 50:855-862 (2003).
  17. McCrossan ZA, Lewis A, Panaghie G, Jordan PN, Christini DJ, Lerner DJ, and Abbott GW, "MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain," Journal of Neuroscience, 23:8077-8091 (2003).
  18. Tang L, Christini DJ, and Edelberg JM, "Genetically engineered biologically based hemostatic bioassay," Annals of Biomedical Engineering, 31:159-162 (2003)
  19. Slotwiner DJ, Christini DJ, Stein KM, Markowitz SM, Mittal S, Iwai S, Das M, and Lerman BB, "Muscle sympathetic nerve traffic during spontaneous vs. adenosine-mediated termination of idiopathic right ventricular outflow tract tachycardia," American Journal of Cardiology, 91:86-88 (2003).
  20. Sinha S and Christini DJ, "Termination of reentry in an inhomogeneous ring of model cardiac cells," Physical Review E, 66:061903-1 -- 061903-7 (2002).
  21. Sinha S, Stein KM, and Christini DJ, "Critical role of inhomogeneities in pacing termination of cardiac reentry," Chaos, 12:893-902 (2002).
  22. Edelberg JM, Jacobson JT, Gidseg DS, Tang L, and Christini DJ, "Enhanced myocyte-based biosensing of the blood-borne signals regulating chronotropy," Journal of Applied Physiology, 92:581-585 (2002).
  23. Christini DJ, Stein KM, Markowitz SM, Mittal S, Slotwiner DJ, Iwai S, and Lerman BB, "Complex AV-nodal dynamics during ventricular-triggered atrial pacing in humans," American Journal of Physiology, 281:H865-H872 (2001).
  24. Christini DJ, Stein KM, Markowitz SM, Mittal S, Slotwiner DJ, Scheiner MA, Iwai S, and Lerman BB, "Nonlinear-dynamical arrhythmia control in humans," Proceedings of the National Academy of Sciences, 98:5827-5832 (2001).
  25. Dorval AD, Christini DJ, and White JA, "Real-Time Linux Dynamic Clamp: A fast and flexible way to construct virtual ion channels in living cells," Annals of Biomedical Engineering, 29:897-907 (2001).
  26. Christini DJ, Walden J, and Edelberg JM, "Direct biologically-based biosensing of dynamic physiological function," American Journal of Physiology, 280:H2006-H2010 (2001).
  27. Hall K and Christini DJ, "Restricted feedback control of one-dimensional maps," Physical Review E, 63:046204-1 -- 046204-9 (2001).
  28. Christini DJ and Kaplan DT, "Adaptive estimation and control method for unstable periodic dynamics in spike trains," Physical Review E, 61:5149-5153 (2000).
  29. Christini DJ, Stein KM, Markowitz SM, and Lerman BB, "A practical real-time computing system for biomedical experiment interface," Annals of Biomedical Engineering, 27:180-186 (1999).
  30. Christini DJ, In V, Spano ML, Ditto WL, and Collins JJ, "Real-time experimental control of a system in its chaotic and nonchaotic regimes," Physical Review E, 56:R3749-R3752 (1997).
  31. Christini DJ and Collins JJ, "Control of chaos in excitable physiological systems: A geometric analysis," CHAOS, 7:544-549 (1997).
  32. Christini DJ and Collins JJ, "Real-time, adaptive, model-independent control of low-dimensional chaotic and nonchaotic dynamical systems," IEEE Transactions on Circuits and Systems-I, 44:1027-1030 (1997).
  33. Hall K, Christini DJ, Tremblay M, Collins JJ, Glass L, and Billette J, "Dynamic control of cardiac alternans," Physical Review Letters, 78:4518-4521 (1997).
  34. Christini DJ, Collins JJ, and Linsay PS, "Experimental control of high-dimensional chaos: The driven double pendulum," Physical Review E, 54:4824-4827 (1996).
  35. Christini DJ and Collins JJ, "Using chaos control and tracking to suppress a pathological nonchaotic rhythm in a cardiac model," Physical Review E, 53:R49-R52 (1996).
  36. Christini DJ and Collins JJ, "Using noise and chaos control to control nonchaotic systems," Physical Review E, 52:5806-5809 (1995).
  37. Christini DJ and Collins JJ, "Controlling non-chaotic neuronal noise using chaos control techniques," Physical Review Letters, 75:2782-2785 (1995).
  38. Christini DJ, Kulkarni A, Rao S, Stutman ER, Bennett FM, Hausdorff JM, Oriol N, and Lutchen KR, "Influence of autoregressive model parameter uncertainty on spectral estimates of heart rate dynamics," Annals of Biomedical Engineering, 23:127-134 (1995).
  39. Christini DJ, Bennett FM, Lutchen KR, Ahmed HM, Hausdorff JM, and Oriol N, "Application of linear and nonlinear time series modeling to heart rate dynamics analysis," IEEE Transactions on Biomedical Engineering, 42:411-415 (1995).

Book Chapters and Reviews:

  1. Krogh-Madsen T, Jordan PN, and Christini DJ, "Control of cardiac electrical nonlinear dynamics," in Scholl E and Schuster HG, eds., Handbook of Chaos Control, 2nd Ed., Verlag GmbH & Co, Weinheim, Germany, 683-701 (2008).
  2. Christini DJ and Lerman BB, "ICD detection of repolarization alternans: Uncovering a marker of electrical instability," Heart Rhythm, 3:798-799 (2006).
  3. Jordan PN and Christini DJ, "Cardiac Arrhythmia," in Akay M, ed., Wiley Encyclopedia of Biomedical Engineering, John Wiley & Sons, Hoboken, NJ, 2:721-730, dx.doi.org/10.1002/9780471740360.ebs0217 (2006).
  4. Jordan PN and Christini DJ, "Therapies for ventricular cardiac arrhythmias," Critical Reviews in Biomedical Engineering, 33:557-604 (2005).
  5. Christini DJ and Glass L, "Mapping and control of complex cardiac arrhythmias," Chaos, 12:732-739 (2002).
  6. Christini DJ, Hall K, Collins JJ, and Glass L, "Controlling cardiac arrhythmias: The relevance of nonlinear dynamics" in Moss F and Gielen S, eds., Handbook of Biological Physics, Volume 4: Neuro-informatics and Neural Modelling, Elsevier, pp. 205-227 (2001).
  7. Christini DJ, Stein KM, Markowitz SM, Mittal S, Slotwiner DJ, and Lerman BB, "The role of nonlinear dynamics in cardiac arrhythmia control," Heart Disease, 1:190-200 (1999).
  8. Christini DJ, Collins JJ, and Linsay PS, "Experimental control of high-dimensional chaos" in Moon FC, ed., Dynamics and Chaos in Manufacturing Processes, John Wiley & Sons, Inc., New York, NY, pp. 303-311 (1998).

Patents: