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74. Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H. (2011) Crystal structure of inhibitor of kappaB kinase beta. Nature, Mar 20. [Epub ahead of print]

73. Liwei Wang, Jin Kuk Yang, Venkataraman Kabaleeswaran, Amanda J. Rice, Anthony C. Cruz, Ah Young Park, Qian Yin, Ermelinda Damko, Se Bok Jang, Stefan Raunser, Carol V. Robinson, Richard M. Siegel, Thomas Walz and Hao Wu (2010). The Fas┐FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat. Struct. Mol. Biol., 17: 1324-9.

71. Su-Chang Lin, Yu-Chih Lo and Hao Wu (2010). Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signaling. Nature, 465: 885-90.

70. Chao Zheng, Venkataraman Kabaleeswaran, Yaya Wang, Genhong Cheng and Hao Wu (2010). Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes ┐ affinity, specificity and regulation. Mol Cell, 38: 101-13.

69. Hao Wu, Yu-Chih Lo and Su-Chang Lin (2010). Recent advances in polyubiquitin chain recognition. F1000 Reports.

68. Qian Yin, Betty Lamothe, Bryant G. Darnay and Hao Wu (2009). Structural basis for the lack of E2 interaction in the RING domain of TRAF2. Biochemistry, 48: 10558-67.

67. Hao Wu and Yu-Chih Lo (2009). Structures, domains and functions in cell death (DD, DED, CARD, PYD). In ENCYCLOPEDIA OF LIFE SCIENCES. John Wiley & Sons Ltd, Chichester.

66. Hao Wu and Sarah G. Hymowitz (2009). Structure and Function of Tumor Necrosis Factor (TNF) at the Cell Surface. HANDBOOK OF CELL SIGNALING, edited by Bradshaw. Pages 265-275.

65. Qian Yin, Su-Chang Lin, Yu-Chih Lo, Steven M. Damo and Hao Wu (2009). Tumor Necrosis Factor Receptor-Associated Factors in Immune Receptor Signal Transduction. HANDBOOK OF CELL SIGNALING, edited by Bradshaw. Pages 339-345.

64. Qian Yin, Su-Chang Lin, Betty Lamothe, Miao Lu, Yu-Chih Lo, Gregory Hura, Lixin Zheng, Rebecca L. Rich, Alejandro D. Campos, David G. Myszka, Michael J. Lenardo, Bryant G. Darnay and Hao Wu (2009). E2 interaction and dimerization in the crystal structure of TRAF6. Nat. Struct. Mol. Biol., 16: 658-66.

63. Yu-Chih Lo, Su-Chang Lin, Carla C. Rospigliosi, Dietrich B. Conze, Chuan-Jin Wu, Jonathan D. Ashwell, David Eliezer and Hao Wu (2009). Crystal structure of NEMO reveals a Novel Mode of Diubiquitin Binding. Mol. Cell 33: 602┐615.

62. Lo YC, Maddineni U, Chung JY, Rich RL, Myszka DG, Wu H. (2008). High-affinity interaction between IKKbeta and NEMO. Biochemistry 47: 3109-16.

61. Lin SC, Chung JY, Lamothe B, Rajashankar K, Lu M, Lo YC, Lam AY, Darnay BG, Wu H. (2008). Molecular Basis for the Unique Deubiquitinating Activity of the NF-kappaB Inhibitor A20. J. Mol. Biol. 376: 526-40.

60. Hao Wu, Jurg Tschopp and Su-Chang Lin (2007). Smac mimetics and TNFalpha: a dangerous liaison? Cell 131: 655-658.

59. Gao Z, Tian Y, Wang J, Yin Q, Wu H, Li YM, Jiang X. (2007). A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP: Dynamic and cooperative regulation of XIAP by Smac/Diablo. J Biol Chem. 282: 30718-27.

58. Lin SC, Huang Y, Lo YC, Lu M, Wu H. (2007). Crystal structure of the BIR1 domain of XIAP in two crystal forms. J. Mol. Biol. 372:847-54.

57. Miao Lu, Su-Chang Lin, Yihua Huang, Young Jun Kang, Rebecca Rich, Yu-Chih Lo, David Myszka, Jiahuai Han and Hao Wu (2007). XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Mol Cell 26: 689-702.

56. Park, H. H., Logette, E., Rauser, S., Cuenin, S., Walz, T., Tschopp, J. & Wu, H. (2007). Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell 128: 533-546.

55. Park, H. H. & Wu, H. (2007). Crystallization and preliminary X-ray crystallographic studies of the oligomeric death domain complex between PIDD and RAIDD. Acta Cryst. F63: 229-32.

54. Park HH, Lo YC, Lin SC, Wang L, Yang JK, Wu H (2007). The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation. Annu Rev Immunol. 25: 561-86.

53. Besse, A., Lamothe, B., Campos, A. D., Webster, W. K., Maddineni, U., Lin, S. C., Wu, H. and Darnay, B. G. (2006). TAK1-dependent signaling requires functional interaction with TAB2/TAB3. J. Biol. Chem. [Epub Ahead of Print]

52. Lamothe B, Besse A, Campos AD, Webster WK, Wu H and Darnay BG (2006). Site-specific K63-linked TRAF6 auto-ubiquitination is a critical determinantof IKK activation. J. Bio. Chem. [Epub Ahead of Print]

51. Park, H. H., Tookes, H. E., and Wu, H. (2006). Crystallization and preliminary X-ray crystallographic studies of Drep-3, a DFF-related protein from Drosophila melanogaster. Acta Crystallograph Sect F Struct Biol Cryst Commun 62, 597-599.

50. Qian Yin, Hyun Ho Park, Jee Y. Chung, Su-Chang Lin, Yu-Chih Lo, Li S. da Graca, Xuejun Jiang, and Hao Wu (2006). Caspase-9 Holoenzyme Is a Specific and Optimal Procaspase-3 Processing Machine. Mol Cell, 22: 259-268.

49. Hyun Ho Park and Hao Wu (2006). Crystal Structure of RAIDD Death Domain Implicates Potential Mechanism of PIDDosome Assembly. J. Mol. Biol., 357: 358-64.

48. Miao Lu, Tongpil Min, David Eliezer and Hao Wu (2006). A novel role for native chemical ligation in covalent caspase inhibition by p35. Chemistry and Biology, 13: 117-22.

47. Jee Chung, Miao Lu, Qian Yin, Su-Chang Lin and Hao Wu (2006). Molecular basis for the unique specificity of TRAF6. In TNF receptor associated factors, in press, and published online on eurekah.com.

46. Jee Chung, Miao Lu, Qian Yin and Hao Wu (2006). Structural revelation of TRAF2 function. In TNF receptor associated factors, in press, and published online on eurekah.com.

45. Jagan R. Muppidi, Adrian A. Lobito, Jin Kuk Yang, Liwei Wang, Hao Wu and Richard M. Siegel (2006). Homotypic FADD interactions though a conserved RXDLL motif are required for death receptor-induced apoptosis. Cell death and differentiation, 13: 1641-50.

44. Ilaria Guasparri, Hao Wu, Ethel Cesarman (2006). The KSHV oncoprotein vFLIP contains a TRAF-interacting motif and requires TRAF2 and TRAF3 for signaling. EMBO Rep., 7: 114-9.

43. Jin Kuk Yang, Liwei Wang, Lixin Zheng, Fengyi Wan, Misonara Ahmed, Michael J. Lenardo and Hao Wu (2005). Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and FLIP Inhibition. Mol Cell, 20: 939-949. (Cover article)

42. Steegborn C, Litvin TN, Hess KC, Capper AB, Taussig R, Buck J, Levin LR and Wu H. (2005). A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen. J Biol. Chem. 280: 31754-9.

41. Steegborn, C., Litvin, T. N., Levin, L. R., Buck, J. and Wu, H. (2005). Bicarbonate activation of adenylyl cyclases via promotion of the catalytic cycle: active site closure and metal recruitment. Nature Struct. & Mol. Biol. 12: 32-7.

40. Ye, H., Chen, T., Xu, X. Pennycooke, M., Wu, H. and Steegborn, C. (2004). Crystal structure of the putative adapter protein MTH1859. J. Struct. Biol. 148: 251-6.

39. Dzivenu, O. K., Park, H. H. and Wu, H. (2004). General co-expression vectors for the overexpression of heterodimeric protein complexes in Escherichia coli. Protein Exp. & Purif. 38: 1-8.

38. Park, H. H. and Wu, H. (2004). Gauging length: recognition of small interfering RNAs. Structure 12: 172-173.

37. Huang, Y., Lu, M. and Wu, H. (2004). XIAP inhibitors for cancer treatment: removing the brakes of apoptosis? Cancer Cell 5:1-2.

36. Joyce Lustbader, Maurizio Cirilli, Chang Lin, Hong Wei Xu, Casper Caspersen, Ning Wang, Kazuhiro Takuma, Xi Chen, Mike Chaney, Fabrizio Trinchese, Shumin Liu, Periannan Kuppusamy, Zay Zewier, Ottavio Arancio, David Stern, Shi Du Yan and Hao Wu (2004). ABAD-Abeta interaction is a direct link from Abeta to mitochondrial toxicity in Alzheimer's disease. Science 304: 448-452.

35. Wu, H. (2004). Assembly of post-receptor signaling complexes for the TNF receptor superfamily. Advances in Protein Chemistry, 68: 226-279.

34. Huang Y, Rich RL, Myszka DG, Wu H. (2003). Requirement of both the BIR2 and BIR3 domains for the relief of XIAP-mediated caspase inhibition by Smac. J. Biol. Chem. 278: 49517-22.

33. Wu, H. and Arron J. (2003). TRAF6, a molecular bridge of adaptive immunity, innate immunity and bone homeostasis. Bioessays, 25: 1096-1105.

32. Chung, J., Park, Y. C., Ye, H. and Wu, H. (2003). TNF receptor associated factors. In Handbook of Cell Signaling, 1: 311-313.

31. Xu G, Rich RL, Steegborn C, Min T, Huang Y, Myszka DG, Wu H. (2003) Mutational Analyses of the p35/caspase Interaction. A bowstring kinetic model of caspase inhibition by P35. J Biol. Chem. 278: 5455-61.

30. Moldovan MC, Yachou A, Levesque K, Wu H, Hendrickson WA, Cohen EA, Sekaly RP. (2002) CD4 dimers constitute the functional component required for T cell activation. J. Immunology 169: 6261-8.

29. Ye, H., Cirilli, M., and Wu, H. (2002). The use of construct variation and diffraction data analysis in the crystallization of the TRAF domain of human tumor necrosis factor receptor associated factor 6. Acta Crystallogr D Biol Crystallogr 58, 1886-1888.

28. Hong Ye, Celine Cande, Nicolas C. Stephanou, Sundeep Gurgusani, Nathanael Larochette, Eric Daugas, Carmen Garrido, Guido Kroemer and Hao Wu (2002). DNA binding as a structural requirement for the apoptogenic action of AIF. Nature Struct. biol. 9: 680-4.

27. Hong Ye, Joseph R. Arron, Betty Lamothe, Maurizio Cirilli, Takashi Kobayashi, Nirupama K. Shevde, Deena Segal, Oki K. Dzivenu, Masha Vologodskaia, Mijung Yim, Khoi Du, Sujay Singh, J. Wesley Pike, Bryant G. Darnay, Yongwon Choi, and Hao Wu (2002). Distinct molecular mechanism for initiating TRAF6 signaling. Nature 418: 443-7.

26. Chung, J., Park, Y. C., Ye, H. and Wu, H. (2002). All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. J. Cell Sci. 115: 679-688.

25. Huang, Y., Park, Y. C., Rich, R. L., Segal, D., Myszka, D. G. and Wu, H. (2001). Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell 104: 781-790.

24. Xu, G., Cirilli, M., Huang, Y., Rich, R. L., Myszka, D. G. and Wu, H. (2001). Covalent inhibition revealed by the crystal structure of the p35/caspase-8 complex. Nature 410: 494.

23. Ni, C. Z., Welsh, K., Leo, E., Chiou, C. K., Wu, H., Reed, J. C., and Ely, K. R. (2000). Molecular basis for CD40 signaling mediated by TRAF3. Proc Natl Acad Sci U S A 97, 10395-9.

22. Park, Y. C., Ye, H., Hsia, C., Segal, D., Rich, R. L., Liou, H. C., Myszka, D. G., and Wu, H. (2000). A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell 101, 777-87.

21. Ye, H., and Wu, H. (2000). Thermodynamic characterization of the interaction between TRAF2 and tumor necrosis factor receptor peptides by isothermal titration calorimetry. Proc Natl Acad Sci U S A 97, 8961-6.

20. Bhargava, G., Mui, S., Pav, S., Wu, H., Loeber, G., and Tong, L. (1999). Preliminary crystallographic studies of human mitochondrial NAD(P)(+)- dependent malic enzyme. J Struct Biol 127, 72-5.

19. Xu, Y., Bhargava, G., Wu, H., Loeber, G., and Tong, L. (1999). Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme: a new class of oxidative decarboxylases. Structure Fold Des 7, R877-89.

18. H. Wu, Y. C. Park, H. Ye and L. Tong (1999). Structural studies of human TRAF2. Cold Spring Harb. Symp. Quant. Biol. (Signaling and Gene Expression in the Immune System), 64: 541-549.

17. Ye, H., Park, Y. C., Kreishman, M., Kieff, E., and Wu, H. (1999). The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol Cell 4, 321-30.

16. Park, Y. C., Burkitt, V., Villa, A. R., Tong, L., and Wu, H. (1999). Structural basis for self-association and receptor recognition of human TRAF2. Nature 398, 533-8.

15. Lustbader, J. W., Lobel, L., Wu, H., Elliott, M. M. (1998). Structural and molecular studies of human chorionic gonadotropin and its receptor. Recent Prog Horm Res 1998;53:395-424; discussion 424-5.

14. H. Wu, P. D. Kwong and W. A . Hendrickson (1997). Dimeric association and segmental variability in the crystal structure of human CD4. Nature, 387: 527-530.

13. H. Wu, D. G. Myszda, S. W. Tendian, C. G. Brouillette, R. W. Sweet, I. M. Chaiken and W. A. Hendrickson (1996). Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding. PNAS, 93: 15030-15035.

12. X. Jiang, M. Dreano, D. R. Buckler, S. Cheng, A. Ythier, H. Wu, W. A. Hendrickson and N. E. Tayar (1995). Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. Structure 3: 1341-1353.

11. J. W. Lustbader, H. Wu, S. Birken, S. Pollak, M. A. G. Kolks, A. M. Pound, D. Austin, W. A. Hendrickson and R. E. Canfield (1995). The expression, characterization and crystallization of wild-type and selenomethionyl hCG. Endocrinology 136: 640-650.

10. J. W. Lustbader, C. Wang, X. Zhang, S. Birken, H. Wu, J. M. Brown, D. Yarmush, S. Pollak & R. E. Canfield (1994). Human chorionic gonadotropin: progress in determining its tertiary structure. in Glycoprotein hormones. pp 81-102. Springer-Verlag, New York.

9. H. Wu, J. W. Lustbader, Y. Liu, R. E. Canfield & W. A. Hendrickson (1994). Structure of human chorionic gonadotropin at 2.6┼ resolution from MAD analysis of the selenomethionyl protein (1994). Structure 2: 545-558. (News & Views in Nature 369: 438-439, 1994).

8. H. Wu and M. G. Rossmann (1993). The canine parvovirus empty capsid structure. J. Mol. Biol. 233: 231-244.

7. H. Wu, W. Keller and M. G. Rossmann (1993). Determination and refinement of the canine parvovirus empty capsid structure. Acta Cryst. D49: 572-579.

6. J. Tsao, M. S. Chapman, H. Wu, M. Agbandje, W. Keller and M.G. Rossmann (1992). The structure determination of monoclinic canine parvovirus. Acta Crystallogr. B48: 75-88.

5. M. G. Rossmann, R. McKenna, L. Tong, D. Xia, J. Dai, H. Wu, H. Choi and R. E. Lynch (1992). Molecular replacement real space averaging. J. Appl. Crystallogr. 25: 166-180.

4. J. Tsao, M. S. Chapman, M. Agbandje, W. Keller, K. Smith, H. Wu, M. Luo, T. J. Smith, M. G. Rossmann, R. W. Compans and C. R. Parrish (1991). The structure of canine parvovirus and its functional implications. Science 251: 1456.

3. Z. X. Gong, H. Wu, R. H. Cheng, R. Hull and M. G. Rossmann (1990). Crystallization of cauliflower mosaic virus. Virology 179: 941.

2. L. Zhu, H. Wu and Y. Dong (1989). Phenotype analysis of T lymphocytes in SLE patients upon flow cytometer. Acta Academiae Medicinal Sinicae 11: 1.

1. L. Zhu, H. Wu and Y. Dong (1988). Establishment of a cell sorting technique with a flow cytometer. Acta Academiae Medicinal Sinicae 10: 386.