We use primarily X-ray crystallography in conjunction with other biophysical and biochemical methods to elucidate the protein-protein interactions involved in the intracellular signaling of cell survival and cell death in response to extracelluar signals.

Inhibitor of Kappa B kinase Beta (IKKbeta)

Nature 472: 325-330 (2011).

The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

Nat Struct Mol Biol. 17:1289-1290 (2010).

Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signaling

Nature 465: 885-890 (2010).

Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes - affinity, specificity and regulation

Mol Cell 38: 101-113 (2010).

Crystal Structure of NEMO Reveals a Novel Mode of Diubiquitin Binding

Mol Cell 33: 602-615 (2009).

E2 interaction and dimerization in the crystal structure of TRAF6

Nature Struct Mol Biol 16: 658-666 (2009).

XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization

Mol Cell 26: 689-702 (2007).

Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core

Cell 128: 533-546 (2007).

Caspase-9 Holoenzyme Is a Specific and Optimal Procaspase-3 Processing Machine

Mol Cell 22: 259-68 (2006).

Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and FLIP Inhibition

Mol Cell 20: 939-49 (2005).

Bicarbonate activation of adenylyl cyclases via promotion of the catalytic cycle: active site closure and metal recruitment

Nature Struct Mol Biol 12: 32-7 (2005).

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

Science 304: 448-452 (2004).

Distinct molecular mechanism for initiating TRAF6 signalling

Nature 418: 443-447 (2002).

DNA binding is required for the apoptogenic action of apoptosis inducing factor

Nature Structural Biology 9: 680-684 (2002).

Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex

Nature 410: 494-497 (2001).

Structural Basis of Caspase Inhibition by XIAP: Differential Roles of the Linker versus the BIR Domain

Cell 104: 781-790 (2001).

A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction

Cell 101: 777-787 (2000).

Structural Basis for Self association and Receptor Recognition of Human TRAF2

Nature 398: 533-538 (1999).

The Structural Basis for the Recognition of Diverse Receptor Sequences by TRAF2

Molecular Cell 4: 321-330 (1999).