Provide the following information for the key personnel in the order listed on Form Page 2.
Photocopy this page or follow this format for each person.
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NAME Jochen Buck |
POSITION TITLE Professor |
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
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INSTITUTION AND LOCATION |
DEGREE (if applicable) |
YEAR(s) |
FIELD OF STUDY |
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University of Tubingen, Germany University of Tubingen, Germany Sloan-Kettering Institute |
M.D. Ph.D. |
1984 1985 |
Medicine Biomedical Sciences Postdoctoral studies |
A. Positions & Honors:
1980-83 Graduate research at Children's Hospital, University of Tubingen.
1984 Resident, Pediatric Oncology and Research Assistant at Children's Hospital, University of Tubingen.
1985-86 Postdoctoral Research Fellow, Sloan-Kettering Institute, Department of Immunology
1987-92 Postdoctoral Research Associate, Sloan-Kettering Institute, Department of Immunology
1992-97 Assistant Professor, Department of Pharmacology, Weill Medical College of Cornell University, New York, NY.
1997-00 Associate Professor, Department of Pharmacology, Weill Medical College of Cornell University, New York, NY.
2000-02 Associate Professor with Tenure, Department of Pharmacology, Weill Medical College of Cornell University, New York, NY.
2002- Professor, Department of Pharmacology, Weill Medical College of Cornell University, New York, NY.
1985 Fellowship from the Mildred Scheel Stiftung, German Cancer Society
1987 Clinical Research Award from the Norma and Rosita Winston Found.
1993 Pew Scholar in the Biomedical Sciences
1998 Hirschl/Weill-Caulier Medical Scholar
2001 Ellison Foundation Scholar
B. Selected bibliography:
Buck, J., G. Bruchelt, J. Treuner and D. Niethammer (1987). Specific uptake of m-[125I]- iodobenzylguanidine in the human neuroblastoma cell line SK-N-SH. Cancer Res. 45: 6366-6370.
Buck, J., U. Hammerling, M. Hoffmann, E. Levi and K. Welte (1987). Purification and biochemical characterization of a human autocrine growth factor produced from EBV transformed B cells. J. Immunol. 138: 2923-2928.
Buck, J., G. Ritter, L. Dannecker, V. Katta, B. Chait and U. Hammerling (1990). Retinol is essential for the growth of activated human B cells. J. Exp. Med. 171: 1613-1624.
Nocka, K., J. Buck, E. Levi and P. Besmer (1990). Candidate ligand for the c-kit transmembrane receptor: KL, a fibroblast-derived growth factor stimulates mast cells and erythroid progenitors. EMBO J. 9: 3287-3294.
Nocka, K., E. Huang, D. R. Beier, C. Tang-Huang, J. Buck, H.-W. Lahm, D. Wellner, P. Leder and P. Besmer (1990). The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell 63: 213-224.
Buck, J., F. Derguini, E. Levi, K. Nakanishi and U. Hammerling (1991). Intracellular signaling by 14 hydroxy-1,14-retro -retinol. Science 254: 1654-1656.
Buck, J., A. Myc, A. Garbe and G. Cathomas (1991). Differences in the action and metabolism between retinol and retinoic acid in B lymphocytes. J. Cell Biol. 115: 851-859.
Garbe, A., J. Buck and U. Hammerling (1992). Retinoids are important cofactors in T cell activation. J. Exp. Med. 176: 109-117.
Huang, E., K. Nocka, J. Buck and P. Besmer (1992). Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2. Mol. Biol. Cell 3: 349-362.
Buck, J., F. Grun, F. Derguini, S. Kimura, N. Noy and U. Hammerling (1993). Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology. J. Exp. Med. 178: 675-680.
Eppinger, T. M., J. Buck and U. Hammerling (1993). Growth control or terminal differentiation: endogenous production and differential activities of vitamin A metabolites in HL-60 cells. J. Exp. Med. 178: 1995-2005.
Kurie, J., J. Buck, T. Eppinger, D. Moy and E. Dmitrovsky (1993). 9-cis and all -trans retinoic acid induce a similar phenotype in human teratocarcinoma cells. Differentiation 54: 123-129.
Derguini, F., K. Nakanishi, J. Buck, U. Hammerling and F. Grun (1994). Spectroscopic studies of anhydroretinol, an endogenous mammalian and insect retro-retinoid. Angewandte Chemie Engl. Edition 33: 1837-1839.
Derguini, F., K. Nakanishi, U. HŠmmerling and J. Buck (1994). Synthesis and intracellular signaling activity of (14R), (14S) and (14RS)-14-Hydroxy-4,14-Retro-Retinol (14-HRR). Biochemistry 33: 623-628.
Derguini, F., K. Nakanishi, U. Hammerling, R. Chua, T. Eppinger, E. Levi and J. Buck (1995). 13,14 Dihydroxy-retinol, a new bioactive retinol metabolite. J. Biol. Chem. 270: 18875-18880.
Blumberg, B., J. Bolado, F. Derguini, A. G. Craig, T. A. Moreno, D. Charkravarti, R. A. Heyman, J. Buck and R. Evans (1996). Novel retinoic acid receptor ligands in Xenopus embryos. Proc. Natl. Acad. Sci USA 93: 4873-4878.
GrŸn, F., N. Noy, U. HŠmmerling and J. Buck (1996). Retinol dehydratase from Spodoptera frugiperda synthesizes growth suppressive anhydroretinol. J. Biol. Chem. 271:16135-16138.
O'Connell, M.J., R. Chua, B. Hoyos, J. Buck, Y. Chen, F. Derguini and U. Hammerling (1996). Retro-retinoids in regulated cell growth and death . J. Exp. Med. 184:549-555.
Chen, Y., F. Derguini and J. Buck (1997). Vitamin A in serum is a survival factor for fibroblasts. Proc. Natl. Acad. Sci USA 94:10205-10208.
Vakiani, E., J.G. Luz, and J. Buck (1998). Substrate specificity and kinetic mechanism of the insect sulfotransferase, retinol dehydratase. J. Biol. Chem. 273:35381-35387.
Buck*, J., M.L. Sinclair*, L. Schapal, M.J. Cann, and L.R. Levin (1999). Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Proc. Natl. Acad. Sci USA 96:79-84.
Chen, Y., J. Buck, and F. Derguini (1999) Anhydroretinol induces oxidative stress and cell death. Cancer Res. 59: 3985-3990.
Sinclair, M.L., X.-Y. Wang, M. Conti, J. Buck, D.J. Wolgemuth, and L.R. Levin (2000). Selective expression of soluble adenylyl cyclase in male germ cells. Mol. Rep. Dev. 56: 6-11.
Chen, Y., and J. Buck (2000). Cannabinoids prevent cells from oxidative cell death. J. Pharm. Exp. Ther. 293: 807-812.
Chen*, Y., M.J. Cann*, T.N. Litvin, V. Iourgenko, M.L. Sinclair, L.R. Levin, and J. Buck (2000). Adenylyl cyclase is an evolutionarily conserved bicarbonate sensor. Science 289: 625-628.
Pakhomova, S., J.G. Luz, M. Kobayashi, D. Mellman, J. Buck, and M.E. Newcomer (2000). Crystallization of retinol dehydratase from Spodoptera frugiperda: Improvement of crystal quality by modification by ethylmercurithiosalicyte, Acta Crystallogr. D. Biol. Crystallogr. 56:1641-1643.
Pakhomova, S., M. Kobayashi, J. Buck, and M.E. Newcomer (2001). Retinol dehydratase is a sulfotransferase with a lipase-like active site lid. Nature Struc. Biol. 8:447-451.
Wuttke, M.S., J. Buck, and L.R. Levin (2001). Bicarbonate-regulated soluble adenylyl cyclase. Journal of the Pancreas. 2: 154-158.
Zippin, J.H., L.R. Levin, and J. Buck (2001). Bicarbonate/CO2 responsive soluble adenylyl cyclase as a putative metabolic sensor. Trends in Endocrinology and Metabolism. 12:366-370.
Buck, J., M.L. Sinclair, and L.R. Levin (2002). Purification of soluble adenylyl cyclase. Methods in Enzymology (G proteins), 345: 95-105.
Zippin, J.H.*, Chen, Y.*, Nahirney, P.*, Kamenetsky, M., Wuttke, M.S., Fischman, D.A., Levin, L.R. and Buck, J. (2003). Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB Journal 17: 82-84.
Sun, X.C., Zhai, C.-B., Miao, C., Chen, Y., Levin, L.R., Buck, J., and Bonanno, J.A. (2003). HCO3-dependent soluble adenylyl cyclase activates the cystic fibrosis transmembrane conductance regulator in corneal endothelium. Am J Physiol Cell Physiol 284: C1114-1122.
Litvin, T.N., Kamenetsky, M., Zarifyan, A., Buck, J. and Levin, L.R. (2003). Kinetic Properties of 'soluble' adenylyl cyclase: synergism between calcium and bicarbonate. J. Biol. Chem. 278:15922-15926.
Pastor-Soler, N., Beaulieu, V., Litvin, T.N., Da Silva, N., Chen, Y., Brown, D., Buck, J., Levin, L.R., and Breton, S. (2003). Bicarbonate regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J. Biol. Chem.278:49523-49529.
Zippin, J.H, Farrel, J., Huron, D., Hess, K.C., Fischman, D.A., Levin, L.R. and Buck, J. (2004) Bicarbonate responsive `soluble` adenylyl cyclase defines a nuclear cAMP microdomain. J. Cell. Biol. 164:527-534.
Kobayashi, M., Buck, J., and Levin, L.R. (2004). Conservation of functional domain structure in bicarbonate-regulated 'soluble' adenylyl cyclases in bacteria and eukaryotes. Dev. Genes & Evol. 214:503-509.
Steegborn, C., Litvin, T.N., Levin, L.R., Buck, J., and Wu, H. (2005). Bicarbonate activation of adenylyl cyclase via promotion of the catalytic cycle: active site closure and metal recruitment. Nature Str. & Mol. Biol. 12:32-37.
Han, H., Stessin, A.M., Roberts, J., Hess, K.C., Gautam, N., Kamenetsky, M., Lou, O., Hyde, E., Nathan, N., Muller, W.A., Buck, J., Levin, L.R., and Nathan, C. (2005). Role of Calcium-Sensing Soluble Adenylyl Cyclase in TNF Signal Transduction in Human Neutrophils. J. Exp. Med. 202:353-361.
Steegborn, C.*, Litvin, T.N.*, Hess, K., Buck, J, Levin, L.R., and Wu, H. (2005). Molecular mechanism of adenylyl cyclases inhibition by catechol estrogen. J. Biol. Chem. 280:31754-9.
Hess, K.C.*, Jones, B.H.*, Marquez, B., Chen, Y., Ord, T.S., Kamenetsky, M., Myamoto, C., Zippin, J.H., Kopf, G.S., Suarez, S.S., Levin, L.R.*, Williams, C.J.*, Buck, J.*, and Moss, S.B.* (2005). ÔSoluble' Adenylyl Cyclase mediates Multiple Specific Signaling Events in Sperm Required for Fertilization. Dev. Cell 9:249-259.
Klengel, T.*, Liang, W-J.*, Chaloupka, J.A.*, Ruoff, C., Schroppel, K., Naglik, J.R., Eckert, S.E., Gewiss, E., Haynes, K., Tuitte, M.F., Levin, L.R., Buck, J., and Muhlschlegel, F.A. (2005). Fungal adenylyl cyclase integrates CO2 sensing with cAMP signalling and virulence. Curr. Biol.15: 2021-2026.
Mogensen, E.G., Janbon, G., Chaloupka, J., Steegborn, C., Fu, M.S., Moyrand, F., Klengel, T., Pearson, D.S., Geeves, M.A., Buck, J., Levin, L.R. and Muhlschlegel, F.A. (2006). Cryptococcus senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. Eukaryotic Cell5:103-111.
Chaloupka, J.A., Bullock, S.A., Iourgenko, V., Levin, L.R., and Buck, J. (2006). Auotinhibitory regulation of soluble adenylyl cyclase. Mol. Repro. & Dev.73: 361-368.
Stessin, A.M., Zippin, J.H., Kamenetsky, M., Hess, K.C., Buck, J., and Levin, L.R. (2006). Soluble adenylyl cyclase mediates NGF-induced activation of RAP1. J. Biol. Chem. 281: 17253-17258.
Kamenetsky, M., Middelhaufe, S. Bank, E.M., Levin, L.R., Buck, J., and Steegborn, C. (2006). Molecular details of cAMP generation in mammalian cells: A tale of two systems. J. Mol. Biol. 362: 623-629.
Wu, K.Y., Zippin, J.H., Huron, D.R., Kamenetsky, M., Hengst, U., Buck, J., Levin, L.R., and Jaffrey, S.R. (2006). Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nature Neuro. 9: 1257-1264.
Beltran, C., Vacquier, V.D., Moy, G., Chen, Y., Buck, J., Levin, L.R., and Darszon, A. (2007). Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction. BBRC 358: 1128-1135.
Schmid, A., Sutto, Z., Nlend, M., Horvath, G., Schmid, N., Buck, J., Levin, L.R., Conner, G., Fregien, N., and Salathe, M. (2007). Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J. Gen. Phys. 130: 99-109.
Young, J.J.*, Mehdi, A.*, Stohl, L., Levin, L.R., Buck, J., Wagner, J.A., and Stessin, A.M. (2007). 'Soluble' adenylyl cyclase-generated cyclic AMP promotes fast migration in PC12 cells. J. Neurosci. Res. 86: 118-124.
Schlicker, C., Rauch, A., Hess, K.C., Kachholz, B., Levin, L.R., Buck, J., and Steegborn, C. (2008). Structure-based development of novel adenylyl cyclase inhibitors. J. Med. Chem. In Press.
Ramos, L.*, Zippin, J.H.*, Kamenetsky, M., Buck, J., and Levin, L.R. (2008). Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J. Gen. Physiol. In Press.
Farrell, J. Tresguerres, M., Ramos, L., Kamenetsky, M., Levin, L.R., and Buck, J. (2008). Somatic ÔsolubleÕ adenylyl cyclase isoforms are unaffected in Sacytm1Lex/Sacytm1Lex ÔknockoutÕ mice. PLoS ONE in revsion.