Point mutation in aGDI that changes prevents its efficient binding to Rab3a. This presumably blocks the dissociation of Rab3a from vesicles, blocking the rab cycle.
model of the Rab cycle (from Olkonen & Ikonen, 2000)
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Point mutation in aGDI that changes prevents its efficient binding to Rab3a. This presumably blocks the dissociation of Rab3a from vesicles, blocking the rab cycle.
model of the Rab cycle (from Olkonen & Ikonen, 2000) |