Diagram of proceedure for gene
disruption by homologous recombination (a.k.a.) :
- return/go to
discussion
on the genes, promoters & DNA page
- The following diagram shows:
- the structure of the targeting vector relative to the genomic
DNA
- what happens during homologous recombination (the intended
event, giving NEOr, TK-)
- what happens if recombination occurs at a non-homologous site
(an untargeted gene is disrupted, giving NEOr, TK+
)
- what happens if no recombination event occurs (no stable
integration, giving NEOs, TK- )
- return/go to
discussion
on the genes, promoters & DNA page
-
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