Selected Publications
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Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H. (2011) Crystal structure of inhibitor of kappaB kinase beta. Nature, Mar 20. [Epub ahead of print] PDF
Liwei Wang, Jin Kuk Yang, Venkataraman Kabaleeswaran, Amanda J. Rice, Anthony C. Cruz, Ah Young Park, Qian Yin, Ermelinda Damko, Se Bok Jang, Stefan Raunser, Carol V. Robinson, Richard M. Siegel, Thomas Walz and Hao Wu (2010). The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat. Struct. Mol. Biol., 17: 1324-9. PDF
Su-Chang Lin, Yu-Chih Lo and Hao Wu (2010). Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signaling. Nature, 465: 885-90.PDF
Chao Zheng, Venkataraman Kabaleeswaran, Yaya Wang, Genhong Cheng and Hao Wu (2010). Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes – affinity, specificity and regulation. Mol Cell, 38: 101-13.PDF
Qian Yin, Su-Chang Lin, Betty Lamothe, Miao Lu, Yu-Chih Lo, Gregory Hura, Lixin Zheng, Rebecca L. Rich, Alejandro D. Campos, David G. Myszka, Michael J. Lenardo, Bryant G. Darnay and Hao Wu (2009). E2 interaction and dimerization in the crystal structure of TRAF6. Nature Struct Mol Biol, 16:658-66 PDF
Yu-Chih Lo, Su-Chang Lin, Carla C. Rospigliosi, Dietrich B. Conze, Chuan-Jin Wu, Jonathan D. Ashwell, David Eliezer and Hao Wu (2009). Structural Basis for Recognition of Diubiquitins by NEMO. Mol Cell 33: 602-615. PDF
Lin SC, Chung JY, Lamothe B, Rajashankar K, Lu M, Lo YC, Lam AY, Darnay BG, Wu H. (2008). Molecular Basis for the Unique Deubiquitinating Activity of the NF-kappaB Inhibitor A20. J. Mol. Biol. 376:526-40. PDF Commentary
Hao Wu, Jurg Tschopp and Su-Chang Lin (2007). Smac mimetics and TNFalpha: a dangerous liaison? Cell 131: 655-658. PDF
Miao Lu, Su-Chang Lin, Yihua Huang, Young Jun Kang, Rebecca Rich, Yu-Chih Lo, David Myszka, Jiahuai Han and Hao Wu (2007). XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Mol Cell 26: 689-702. PDF
Park, H. H., Logette, E., Rauser, S., Cuenin, S., Walz, T., Tschopp, J. & Wu, H. (2007). Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell 128: 533-546. PDF
Qian Yin, Hyun Ho Park, Jee Y. Chung, Su-Chang Lin, Yu-Chih Lo, Li S. da Graca, Xuejun Jiang, and Hao Wu (2006). Caspase-9 Holoenzyme Is a Specific and Optimal Procaspase-3 Processing Machine. Mol Cell, 22: 259-268. PDF
Miao Lu, Tongpil Min, David Eliezer and Hao Wu (2006). A novel role for native chemical ligation in covalent caspase inhibition by p35. Chemistry and Biology, 13: 117-22. PDF Commentary
Jin Kuk Yang, Liwei Wang, Lixin Zheng, Fengyi Wan, Misonara Ahmed, Michael J. Lenardo and Hao Wu (2005). Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and FLIP Inhibition. Mol Cell, 20: 939-949. (Cover article) PDF
Steegborn, C., Litvin, T. N., Levin, L. R., Buck, J. and Wu, H. (2005). Bicarbonate activation of adenylyl cyclases via promotion of the catalytic cycle: active site closure and metal recruitment. Nature Struct. & Mol. Biol. 12: 32-7. PDF Commentary
Huang, Y., Lu, M. and Wu, H. (2004). XIAP inhibitors for cancer treatment: removing the brakes of apoptosis? Cancer Cell 5:1-2. PDF
Joyce Lustbader, Maurizio Cirilli, Chang Lin, Hong Wei Xu, Casper Caspersen, Ning Wang, Kazuhiro Takuma, Xi Chen, Mike Chaney, Fabrizio Trinchese, Shumin Liu, Periannan Kuppusamy, Zay Zewier, Ottavio Arancio, David Stern, Shi Du Yan and Hao Wu (2004). ABAD-Abeta interaction is a direct link from Abeta to mitochondrial toxicity in Alzheimer's disease. Science 304: 448-452. PDF
Hong Ye, Celine Cande, Nicolas C. Stephanou, Sundeep Gurgusani, Nathanael Larochette, Eric Daugas, Carmen Garrido, Guido Kroemer and Hao Wu (2002). DNA binding as a structural requirement for the apoptogenic action of AIF. Nature Struct. biol. 9: 680-4. PDF
Hong Ye, Joseph R. Arron, Betty Lamothe, Maurizio Cirilli, Takashi Kobayashi, Nirupama K. Shevde, Deena Segal, Oki K. Dzivenu, Masha Vologodskaia, Mijung Yim, Khoi Du, Sujay Singh, J. Wesley Pike, Bryant G. Darnay, Yongwon Choi, and Hao Wu (2002). Distinct molecular mechanism for initiating TRAF6 signaling. Nature 418: 443-7. PDF
Huang, Y., Park, Y. C., Rich, R. L., Segal, D., Myszka, D. G. and Wu, H. (2001). Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell 104: 781-790. PDF
Xu, G., Cirilli, M., Huang, Y., Rich, R. L., Myszka, D. G. and Wu, H. (2001). Covalent inhibition revealed by the crystal structure of the p35/caspase-8 complex. Nature 410: 494. PDF
Park, Y. C., Ye, H., Hsia, C., Segal, D., Rich, R. L., Liou, H. C., Myszka, D. G., and Wu, H. (2000). A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell 101, 777-87. PDF
Ye, H., and Wu, H. (2000). Thermodynamic characterization of the interaction between TRAF2 and tumor necrosis factor receptor peptides by isothermal titration calorimetry. Proc Natl Acad Sci U S A 97, 8961-6. PDF
Ye, H., Park, Y. C., Kreishman, M., Kieff, E., and Wu, H. (1999). The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol Cell 4, 321-30. PDF
Park, Y. C., Burkitt, V., Villa, A. R., Tong, L., and Wu, H. (1999). Structural basis for self-association and receptor recognition of human TRAF2. Nature 398, 533-8. PDF
H. Wu, P. D. Kwong and W. A . Hendrickson (1997). Dimeric association and segmental variability in the crystal structure of human CD4. Nature, 387: 527-530. PDF