General anesthesia, sleep, and coma

Emery N. Brown, Ralph Lydic, and Nicholas D. Schiff

New Engl. J. Med. 363, 2638-2650 (2010)

Summary

This review discusses the clinical and neurophysiological features of general anesthesia and their relationships to sleep and coma, focusing on the neural mechanisms of unconsciousness induced by selected intravenous anesthetic drugs.