A neuromodulation strategy for rational therapy of complex brain injury states

Nicholas D. Schiff, Ali Rezai, and Fred Plum

Neurol. Res. 22, 267-272 (2000)

Abstract

We review initial efforts at neuromodulation in the vegetative state and organize several aspects of recent studies of the underlying neurobiology of castastrophic brain injuries.An innovative strategy for patient and target selection for neuromodulation of impaired cognitive function is outlined.Scientific and ethical issues that will attend future efforts ot appropriately risk-stratify patients and initiate interventions with therapeutic intent are considered.