Timothy A. Ryan, Ph.D.  Laboratory

Synaptic Proteins
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Vesicle Trafficking

Welcome to the Web site of the lab of Timothy A. Ryan, Ph.D.  in

the Department of Biochemistry at the

Weill Medical College of Cornell University.                  Cornell Calendar of upcoming events

                                                                                         Cornell Intranet

                                                                             The Rockefeller University  Calendar of Events                                                    

                                                     Memorial Sloan-Kettering Cancer Center Calendar of Events

The lab participates the following programs:               

Graduate Program in Structural Biology and Biochemistry

Graduate Program in Neuroscience

The David Rockefeller Graduate Program of Rockefeller University

Cornell/Rockefeller/Sloan Kettering Tri-Institutional Training Program in Chemical Biology

Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD/PhD Training Program

Program in Cell Biology, Memorial Sloan-Kettering Institute


Physical Chemistry of the Synapse

The focus of this lab is the study of the molecular basis of synaptic transmission in the mammalian brain. Our primary interests lie in understanding the regulation of vesicle traffic in presynaptic terminals, and how this traffic impacts presynaptic function.

We use biophysical tools to measure vesicle trafficking events in individudal presynaptic boutons and molecular, chemical and genetic tools to investigate the role of specific proteins in these events. We concentrate heavily on state-of-the-art optical methods to obtain a quantitative understanding of presynaptic function and attempt to reduce the complexities of synaptic transmission in a physico-chemical framework.

T. A. Ryan 2004 all rights reserved.

 jns_small.JPG (11452 bytes)                               vSNARE.JPG (90035 bytes)                          cover.jpg                                                                   

GFP labeled dendrites and axons in living         SNAREs during recycling imaged                synataxin Ia distribution in

hippocampal neurons in culture (green)               ith synapto-pHluorin (green)             living cells vizualized with pHluorin

                                               Synaptic vesicle clusters visualized using FM 4-64 (red)



             synapsin-small.tif (888416 bytes)                                                      

              GFP-synapsin Ia distribution                               Recycling vesicle clusters in synaptotagmin I KO synaptic terminals




This page was last updated on 11/17/05.