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Welcome to the Web site of the lab of Timothy A. Ryan, Ph.D. in the Department of Biochemistry at the Weill Medical College of Cornell University. Cornell Calendar of upcoming events The Rockefeller University Calendar of Events Memorial Sloan-Kettering Cancer Center Calendar of Events The lab participates the following programs:
Physical Chemistry of the Synapse The focus of this lab is the study of the molecular basis of synaptic transmission in the mammalian brain. Our primary interests lie in understanding the regulation of vesicle traffic in presynaptic terminals, and how this traffic impacts presynaptic function. We use biophysical tools to measure vesicle trafficking events in individudal presynaptic boutons and molecular, chemical and genetic tools to investigate the role of specific proteins in these events. We concentrate heavily on state-of-the-art optical methods to obtain a quantitative understanding of presynaptic function and attempt to reduce the complexities of synaptic transmission in a physico-chemical framework. ã T. A. Ryan 2004 all rights reserved. GFP labeled dendrites and axons in living SNAREs during recycling imaged synataxin Ia distribution in hippocampal neurons in culture (green) ith synapto-pHluorin (green) living cells vizualized with pHluorin Synaptic vesicle clusters visualized using FM 4-64 (red)
GFP-synapsin Ia distribution Recycling vesicle clusters in synaptotagmin I KO synaptic terminals .
This page was last updated on 11/17/05.
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