Selected publications of Keith P. Purpura

A list of selected publications follows. For briefer lists in specific areas, use these links:


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Last revised: 12/24/23

Baker, J.L., Toth, R., Deli, A., Zamora, M., Fleming, J.E., Benjaber, M., Goerzen, D., Ryou, J.W., Purpura, K.P., Schiff, N.D. and Denison, T. (2023) Regulation of arousal and performance of a healthy non-human primate using closed-loop central thalamic deep brain stimulation. Int IEEE EMBS Conf Neural Eng 2023: 10123754.
PMC

Guidolin, A., Desroches, M., Victor, J.D., Purpura, K.P., and Rodrigues, R. (2022) Geometry of spiking patterns in early visual cortex: a topological data analytic approach. Journal of the Royal Society Interface 19: 20220677.
Abstract and download

Janson, A.P., Baker, J.L., Sani,I., Purpura, K.P., Schiff, N.D., and Butson, C.R. (2021) Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates. Scientific Reports 11, 23054.
Abstract and download

Yao, L., Baker, J.L., Schiff, N.D., Purpura, K.P., Shoaran M. (2021) Predicting task performance from biomarkers of mental fatigue in global brain activity. J Neural Eng. 2021 Mar 8;18(3):10.1088/1741-2552/abc529.
Abstract and download

Baker, J. L., Ryou, J.-W., Wei, X.F., Butson, C.R., Schiff, N.D., and Purpura, K.P.(2016) Robust modulation of arousal regulation, performance and frontostriatal activity through central thalamic deep brain stimulation in healthy non-human primates. J Neurophysiol. 116, 2383-2404.
Abstract and download

Schmid, A.M., Purpura, K.P., and Victor, J.D. (2014) Responses to orientation discontinuities in V1 and V2: Physiological dissociations and functional implications. J. Neurosci. 34, 3559–3578.
Abstract and download

Ohiorhenuan, I.E., Mechler, F., Purpura, K.P., Schmid, A.M., Hu, Q., and Victor, J.D. (2014) Cannabinoid neuromodulation in the adult early visual cortex. PLoS ONE 9, e87362.
Abstract, download, and supplement

Schiff, N.D., Shah, S.A., Hudson, A.E., Nauvel, T., Kalik, S.F., and Purpura, K.P. (2013) Gating of attentional effort through the central thalamus. J. Neurophysiol. 109, 1152-1163.
Abstract and download

Ohiorhenuan, I.E., Mechler, F., Purpura, K.P., Schmid, A.M., and Victor, J.D. (2010) Sparse coding and high-order correlations in fine-scale cortical networks. Nature 466, 617–621.
Abstract and download

Victor, J.D., and Purpura, K.P. (2010) Spike Metrics. In: Analysis of Parallel Spike Trains. Ed. Stefan Rotter and Sonja Gruen. Springer, pp. 129-156.
Abstract and download

Menzer, D.L., Bokil, H., Ryou, J.W., Schiff, N.D., Purpura, K.P., and Mitra, P.P. (2009) Characterization of trial-to-trial fluctuations in local field potentials recorded in cerebral cortex of awake behaving macaque. J. Neurosci. Methods 186, 250-261.
Abstract and download

Shah, S.A., Baker, J.L., Ryou, J.W., Purpura, K.P., and Schiff, N.D. (2009) Modulation of arousal regulation with central thalamic deep brain stimulation. Conf. Proc. IEEE. Eng. Med. Biol. Soc. 1, 3314-3317.
Abstract and download

Victor, J.D., Mechler, F., Ohiorhenuan, I.E., Schmid, A., and Purpura, K.P. (2009) Laminar and orientation-dependent characteristics of spatial nonlinearities: implications for the computational architecture of visual cortex. Journal of Neurophysiology 102, 3414-3432.
Abstract and download

Schmid, A.M., Purpura, K.P., Ohiorhenuan, I.E., Mechler, F., and Victor, J.D. (2009) Subpopulations of neurons in visual area V2 perform differentiation and integration operations in space and time. Frontiers in Systems Neuroscience 3, 15, doi:10.3389/neuro.06.015.2009.
Abstract and download

Hudson, A.E., Schiff, N.D., Victor, J.D, and Purpura, K.P. (2009) Attentional modulation of adaptation in V4. Eur. J. Neurosci. 30,151-171.
Abstract and download

Smith, A.C., Shah, S., Hudson, A.E., Purpura, K.P., Victor, J.D., Brown, E.N., and Schiff, N.D. (2009) A Bayesian statistical analysis of behavioral facilitation associated with deep brain stimulation. J. Neurosci. Meth. 183, 267-276.
Abstract and download

Purpura, K.P. and Bokil, H.S. (2008) Neural signal processing: Tutorial I. In: Neural Signal Processing: Quantitative Analysis of Neural Activity, (Mitra P., ed), 67-77. Washington, DC: Society for Neuroscience.
Introduction and download

Bokil, H.S., Purpura, K., Schoffelen, J.-M., Thomson, D., and Mitra, P.P. (2007) Comparing spectra and coherences for groups of unequal size. J. Neurosci. Methods 159, 337-345.
Abstract and download

Victor, J.D., Mechler, F., Repucci, M.A., Purpura, K.P., and Sharpee, T. (2006) Responses of V1 neurons to two-dimensional Hermite functions. J. Neurophysiol. 95, 379-400.
Abstract, related presentations, code, erratum, and download

Purpura, K.P., Kalik, S., and Schiff, N.D. (2003) Analysis of perisaccadic field potentials in the occipitotemporal pathway during active vision. J. Neurophysiol. 90, 3455-3478.
Abstract and download

Schiff, N.D and Purpura, K.P. (2002) Towards a neurophysiological foundation for cognitive neuromodulation through deep brain stimulation. Thalamus and Related Systems 2, 55-69.
Abstract and download

Levine, B.K., Beason-Held, L.L., Purpura, K.P., Aronchick, D.M., Optican, L.M.,Alexander, G.E., Horwitz, B., Rapoport, S.I., and Schapiro, M.B. (2000) Age-related differences in visual perception: a PET study. Neurobiology of Aging 21, 577-584.
Abstract and download

Reich, D.S., Mechler, F., Purpura, K.P., and Victor, J.D. (2000) Interspike intervals, receptive fields, and information encoding in primary visual cortex. J. Neurosci. 20, 1964-1974.
Abstract and downloads

Victor, J.D., and Purpura, K.P. (1999) Estimation of information in neuronal responses. Trends in Neurosciences 22, 543.
Text and references

Schiff, N.D., Purpura, K.P., and Victor, J.D. (1999) Gating of local network signals appears as stimulus-dependent activity envelopes in striate cortex. J. Neurophysiol. 82, 2182-2196.
Abstract, key figure, and downloads

Beason-Held, L.L., Purpura, K.P., Krasuski, J.S., Maisog, J.Ma., Daly, E.M., Mangot, D.J., Desmond, R.E., Optican, L.M., Schapiro, M.B. and Van Meter, J.W. (1998) Cortical regions involved in texture perception: a fMRI study. Cognitive Brain Research 7, 111-118.
Abstract and download

Mechler, F., Victor, J.D., Purpura, K.P., and Shapley, R. (1998) Robust temporal coding of contrast by V1 neurons for transient but not steady-state stimuli. J. Neurosci. 18, 6583-6598.
Abstract and downloads

Victor, J.D., and Purpura, K.P. (1998) Spatial phase and the temporal structure of the response to gratings in V1. J. Neurophysiol. 80, 554-571.
Abstract and downloads

Beason-Held, L.L., Purpura, K.P., Van Meter, J.W., Azari, N.P., Mangot, D.J., Optican, L.M., Mentis, M.J., Alexander, G.E., Grady, C.L., Horwitz, B., Rapoport, S.I., and Schapiro, M.B. (1998) PET reveals occipitotemporal pathway activation during elementary form perception in humans. Visual Neuroscience 15, 503-510.
Abstract and download

Victor, J.D., Purpura, K.P., and Conte, M.M. (1998) Chromatic and luminance interactions in spatial contrast signals. Visual Neuroscience 15, 607-624.
Abstract, key figure, and download

Purpura, K.P., and Schiff, N.D. (1997) The thalamic intralaminar nuclei: A role in visual awareness. The Neuroscientist 3, 8-15.
Abstract and download

Victor, J.D., and Purpura, K.P. (1997) Sensory coding in cortical neurons: recent results and speculations. In: Frontiers of Neurology: A Symposium in Honor of Fred Plum. Annals of the New York Academy of Sciences 835, 330-352.
Abstract and key figures

Victor, J.D., and Purpura, K. (1997) Metric-space analysis of spike trains: theory, algorithms, and application. Network 8, 127-164.
Abstract, code, and downloads

Victor, J.D., Conte, M.M., and Purpura, K.P. (1997) Dynamic shifts of the contrast-response function. Visual Neuroscience 14, 577-587.
Abstract

Victor, J.D., and Purpura, K. (1996) Nature and precision of temporal coding in visual cortex: a metric-space analysis. J. Neurophysiol. 76, 1310-1326.
Summary, key figure, code, and downloads

Victor, J.D., Conte, M.M., Purpura, K., and Katz, E. (1995) Isodipole textures: a window on cortical mechanisms of form processing. In Early Vision and Beyond. eds. T. Papathomas, C. Chubb, A. Gorea, E. Kowler. Cambridge, The MIT Press. pp. 99 - 107.
Abstract, summary, and key figure

Victor, J.D., Purpura, K., Katz, E., and Mao, B. (1994) Population encoding of spatial frequency, orientation, and color in macaque V1. J. Neurophysiol. 72, 2151-2166.
Summary, key figure, and downloads

Purpura, K., Victor, J.D., and Katz, E. (1994) Striate cortex extracts higher-order spatial correlations from visual textures. Proc. Natl. Acad. Sci. USA 91, 8482-8486.
Abstract and download

Shapley, R., Kaplan, E., and Purpura, K. (1993) Contrast sensitivity and light adaptation in photoreceptors or in the retinal network. In: Contrast Sensitivity, R. Shapley and D. M-K Lam, eds., pp 103-116, MIT Press, Cambridge, MA.
Introduction and download


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