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Cornell Pediatrics

Creatinine Clearance

Calculate creatinine clearance (glomerular filtration rate) from a timed urine collection (time, volume, and creatinine concentration), and plasma creatinine. In pediatrics, it is generally corrected to a body surface area of 1.73 m2 (standard body surface area of an adult).

Input Collection Time hr  
Input Urine Volume mL  
Input Urine Creatinine mg/dL  
Input Plasma Creatinine mg/dL  
For correction for BSA, input weight and height:
Input Weight kg lbs
Input Height cm in
 
 
CrCl = 
 mL/min  
Corrected CrCl = 
 mL/min/1.73*m2

 

The formula for the calculation is as below. The BSA here is calculated from the height and weight with the formula of DuBois and DuBois.

CrCl = UCr * UVol
PCr * Tmin

Corrected CrCl = CrCl * 1.73
BSA

Reference range in our laboratory of an "uncorrected" creatinine clearance for an adult male is 90-139 mL/minute, and for an adult female is 80-125 mL/minute. Many medications must be adjusted for renal impairment when the CrCl falls below 50 mL/min. Creatinine clearance often overestimates actual glomerular filtration rate by 10-20% because of active secretion in the peritubular capillaries.

 

Created: January 7, 2000
Revised: September 28, 2010

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