Creatinine Clearance

Calculate creatinine clearance (glomerular filtration rate) from a timed urine collection (time, volume, and creatinine concentration), and plasma creatinine. In pediatrics, it is generally corrected to a body surface area of 1.73 m² (standard body surface area of an adult).

Input Collection Time	hr
Input Urine Volume	mL
Input Urine Creatinine	mg/dL
Input Plasma Creatinine	mg/dL
For correction for BSA, input weight and height:
Input Weight	kg	lbs
Input Height	cm	in



CrCl =	mL/min
Corrected CrCl =	mL/min/1.73*m²

The formula for the calculation is as below. The BSA here is calculated from the height and weight with the formula of DuBois and DuBois.

CrCl =	U_Cr * U_Vol

	P_Cr * T_min

Corrected CrCl = CrCl *	1.73

	BSA

Reference range in our laboratory of an "uncorrected" creatinine clearance for an adult male is 90-139 mL/minute, and for an adult female is 80-125 mL/minute. Many medications must be adjusted for renal impairment when the CrCl falls below 50 mL/min. Creatinine clearance often overestimates actual glomerular filtration rate by 10-20% because of active secretion in the peritubular capillaries.

Created: January 7, 2000
Revised: September 28, 2010