Standards message here
Calculate creatinine clearance (glomerular filtration rate) from a timed urine collection (time, volume, and creatinine concentration), and plasma creatinine. In pediatrics, it is generally corrected to a body surface area of 1.73 m2 (standard body surface area of an adult).
The formula for the calculation is as below. The BSA here is calculated from the height and weight with the formula of DuBois and DuBois.
|CrCl =||UCr * UVol|
|PCr * Tmin|
|Corrected CrCl = CrCl *||1.73|
Reference range in our laboratory of an "uncorrected" creatinine clearance for an adult male is 90-139 mL/minute, and for an adult female is 80-125 mL/minute. Many medications must be adjusted for renal impairment when the CrCl falls below 50 mL/min. Creatinine clearance often overestimates actual glomerular filtration rate by 10-20% because of active secretion in the peritubular capillaries.
Revised: September 28, 2010