Selected publications of Nicholas D. Schiff

A list of selected publications follows. For briefer lists in specific areas, use these links:


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Last revised: 10/24/2014

Forgacs, P.B., Conte, M.M., Fridman, E.A., Voss, H.U., Victor, J.D., and Schiff, N.D. (2014) Preservation of EEG organization in patients with impaired consciousness and imaging-based evidence of command-following. Annals of Neurology, in press.
Abstract and download

Fridman, E.A., Beattie, B., Broft, A., Laureys, S., and Schiff, N.D. (2014) Regional cerebral metabolic patterns demonstrate the role of anterior forebrain mesocircuit dysfunction in the severely injured brain. Proc. Natl. Acad. Sci. USA 111, 6473-6478.
Abstract and download

Giacino, J.T., Fins, J.J., Laureys, S., and Schiff, N.D. (2014) Disorders of consciousness after acquired brain injury: the state of the science. Nature Reviews Neurology 10, 99–114.
Abstract and download

Schiff, N.D., Nauvel, T., and Victor, J.D. (2014) Large-scale brain dynamics in disorders of consciousness. Current Opinion in Neurobiology 25, 7-14.
Abstract and download

Harris, A.L., Elder, J., Schiff, N.D., Victor, J.D., and Goldfine, A.M. (2014) Post-stroke apathy and hypersomnia lead to worse outcomes from acute rehabilitation. Translational Stroke Research 5, 292-300.
Abstract and download

Schiff, N.D. (2013) Central thalamic deep brain stimulation for support of forebrain arousal regulation in the minimally conscious state. Handbook of clinical Neurology 116 (series 3), 295–306.
Abstract and download

Schiff, N.D. (2013) Making waves in consciousness research. Science Translational Medicine 5, 198fs32.
Abstract and download

Paulson, S., Chalmers, D., Kahneman, D., Santos, L., and Schiff, N.D. (2013) The thinking ape: the enigma of human consciousness. Annals of the New York Academy of Sciences 1303, 4–24.
Abstract and download

Williams, S.T., Conte, M.M., Goldfine, A.M., Noirhomme, Q., Gosseries, O., Thonnard, M., Beattie, B., Hersh, J., Katz, D.I., Victor, J.D., Laureys, S., and Schiff, N.D. (2013) Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severely brain-injured subjects. eLife 2013;2:e01157.
Abstract, download, and editorial

Schiff, N.D., Shah, S.A., Hudson, A.E., Nauvel, T., Kalik, S.F., and Purpura, K.P. (2013) Gating of attentional effort through the central thalamus. J. Neurophysiol. 109, 1152-1163.
Abstract and download

Goldfine, A.M., Bardin, J.C., Noirhomme, Q., Fins, J.J., Schiff, N.D., and Victor, J.D. (2013) Reanalysis of “Bedside detection of awareness in the vegetative state: a cohort study.” Lancet 381, 289-291.
Summary, download, and link to further comments

Laureys, S., and Schiff, N.D. (2012) Coma and consciousness: Paradigms (re)framed by neuroimaging. NeuroImage 61, 478–491.
Abstract and download

Schiff, N.D. (2012) Moving toward a generalizable application of central thalamic deep brain stimulation for support of forebrain arousal regulation in the severely injured brain. Annals of the New York Academy of Sciences 1265, 56–68.
Abstract and download

Schiff, N.D. (2012) Posterior medial corticothalamic connectivity and consciousness. Annals of Neurology 72, 305–306.
Abstract and download

Goldfine, A.M., Victor, J.D., Conte, M.M., Bardin, J.C., and Schiff, N.D. (2012) Bedside detection of awareness in the vegetative state (Letter re Cruse et al. (2011)) Lancet, 379, 1701-1702.
Summary and download

Bardin, J.C., Schiff, N.D., and Voss, H.U. (2012) Pattern classification of volitional functional magnetic resonance imaging responses in patients with severe brain injury. Arch Neurol. 69, 176-181
Abstract and download

Goldfine, A.M., and Schiff, N.D. (2011) What is the role of brain mechanisms underlying arousal in recovery of motor function after structural brain injuries? Current Opinion in Neurology 24, 564–569.
Abstract and download

Voss, H.U., Heier, L.A., and Schiff, N.D. (2011) Multimodal imaging of recovery of functional networks associated with reversal of paradoxical herniation after cranioplasty. Clinical Imaging 35, 253–258.
Abstract and download

Liu, A. A., Voss, H.U., Dyke, J.P., Heier, L.A., and Schiff, N.D. (2011) Arterial spin labeling and altered cerebral blood flow patterns in the minimally conscious state. Neurology 77, 1518-23.
Abstract, download, and editorial

Goldfine, A.M., and Schiff, N.D. (2011) Consciousness: Its neurobiology and the major classes of impairment. Neurol. Clin. 29, 723–737.
Summary and download

Goldfine, A.M., Victor, J.D., Conte, M.M., Bardin, J.C., and Schiff, N.D. (2011) Determination of awareness in patients with severe brain injury using EEG power spectral analysis. Clinical Neurophysiology 122, 2157-2168.
Abstract, download, and supplement

Bardin, J.C., Fins, J.J., Katz, D.I., Hersh, J., Heier, L.A., Tabelow, K., Dykep, J.P., Ballon, D.J., Schiff, N.D., and Voss, H.U.(2011) Dissociations between behavioural and functional magnetic resonance imaging-based evaluations of cognitive function after brain injury. Brain 134, 769-782.
Abstract and download

Victor, J.D., Drover, J.D., Conte, M.M., and Schiff, N.D. (2011) Mean-field modeling of thalamocortical dynamics, and a model-driven approach to EEG analysis. Proc. Natl. Acad. Sci. USA 108, 15631-15638.
Abstract and download

Fins, J.J., and Schiff, N.D. (2010) Conflicts of interest in deep brain stimulation research and the ethics of transparency. The Journal of Clinical Ethics, 21, 125–32.
Abstract and download

Fins, J.J., and & Schiff, N.D. (2010) In the blink of the mind’s eye The Hastings Center Report, 40, 21–23.
Abstract and download

Schiff, N.D. (2010) Recovery of consciousness after severe brain injury: the role of arousal regulation mechanisms and some speculation on the heart-brain interface. Cleveland Clinic Journal of Medicine 77 Suppl 3, S27–33.
Abstract and download

Brown, E.N., Lydic, R., and Schiff, N.D. (2010) General anesthesia, sleep, and coma New Engl. J. Med. 363, 2638-2650
Summary and download

Drover, J.D., Schiff, N.D., and Victor, J.D. (2010) Dynamics of coupled thalamocortical modules. Journal of Computational Neuroscience 28, 605-616.
Abstract and download

Schiff, N.D., and Laureys, S. (2009) Disorders of consciousness: Preface. Annals of the New York Academy of Sciences 1157, ix–xi.
Abstract and download

Schiff, N.D. (2009) Recovery of consciousness after brain injury: a mesocircuit hypothesis. Trends in Neuroscience 33, 1-9.
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Owen, A.M., Schiff, N.D., and Laureys, S. (2009) A new era of coma and consciousness science. Progress in Brain Research 117, 399-411.
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Hudson, A.E., Schiff, N.D., Victor, J.D, and Purpura, K.P. (2009) Attentional modulation of adaptation in V4. Eur. J. Neurosci. 30,151-171.
Abstract and download

Schiff, N.D. (2009) Central thalamic deep-brain stimulation in the severely injured brain: rationale and proposed mechansims of action. Ann. NY Acad. of Sci. 1157, 101-116.
Abstract and download

Voss, H.U., and Schiff, N.D. (2009) MRI of neuronal network structure, function and plasticity. Progress in Brain Research 175, 483-496.
Abstract and download

Schiff, N.D., Giacino, J.T.,and Fins, J.J. (2009) Deep brain stimulation, neuroethics, and the minimally conscious state: moving beyond proof of principle. Arch Neurol. 66, 697-702.
Abstract and download

Menzer, D.L., Bokil, H., Ryou, J.W., Schiff, N.D., Purpura, K.P., and Mitra, P.P. (2009) Characterization of trial-to-trial fluctuations in local field potentials recorded in cerebral cortex of awake behaving macaque. J. Neurosci. Methods 186, 250-261.
Abstract and download

Shah, S.A., Baker, J.L., Ryou, J.W., Purpura, K.P., and Schiff, N.D. (2009) Modulation of arousal regulation with central thalamic deep brain stimulation. Conf. Proc. IEEE. Eng. Med. Biol. Soc. 1, 3314-3317.
Abstract and download

Smith, A.C., Shah, S., Hudson, A.E., Purpura, K.P., Victor, J.D., Brown, E.N., and Schiff, N.D. (2009) A Bayesian statistical analysis of behavioral facilitation associated with deep brain stimulation. J. Neurosci. Meth. 183, 267-276.
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Bohland, J.W., Wu, C., Barbas, H., Bokil, H., Bota, M., Breiter, H.C., Cline, H.T., Doyle, J.C., Freed, P.J., Greenspan, R.J., Haber, S.N., Hawrylycz, M., Herrera, D.G., Hilgetag, C.C., Huang, Z.J., Jones, A., Jones, E.G., Karten, H.J., Kleinfeld, D., K๖tter, R., Lester, H.A., Lin, J.M., Mensh, B.D., Mikula, S., Panksepp, J., Price, J.L., Safdieh, J., Saper, C.B., Schiff, N.D., Schmahmann, J.D., Stillman, B.W., Svoboda, K., Swanson, L.W., Toga, A.W., Van Essen, D.C., Watson, J.D., Mitra, P.P. (2009) A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. PLoS Comput. Biol. 5(3):e1000334.
Abstract and download

Schiff, N.D. (2008) Central thalamic contributions to arousal regulation and neurological disorders of consciousness. Ann. NY Acad. of Sci. 1129, 105-118.
Abstract and download

Smart, C.M., Giacino, G.T., Cullen, T., Rodriguez-Moreno, D., Hirsch, J., Schiff, N.D., and Gizzi, M. (2008) A case of locked-in syndrome complicated by central deafness. Nature Clin. Pract. Neurol.4, 448-453.
Abstract and download

Victor, J.D., and Schiff, N.D. (2008) Meeting rigorous statistical standards in case reports. Annals of Neurology 64, 592.
Letter and download

Schiff, N.D., and Fins, J.J. (2007). Deep brain stimulation and cognition: moving from animal to patient. Current Opinion in Neurology 20, 638–642.
Abstract and download

Schiff, N.D. (2007) Bringing neuroimaging tools closer to diagnostic use in the severely injured brain. Brain 130, 2482–2483.
Abstract and download

Schiff, N.D., Giacino, J.T., Kalmar, K., Victor, J.D., Baker, K., Gerber, M., Fritz, B., Eisenberg, B., Biondi, T., O'Connor, J., Kobylarz, E.J., Farris, S., Machado, A., McCagg, C., Plum, F., Fins, J.J., and Rezai, A. R. (2007) Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 448, 600-603.
Abstract and related material

Fins, J.J., Schiff, N.D., and Foley, K.M. (2007) Late recovery from the minimally conscious state: Ethical and policy implications. Neurology 68, 304-307.
Abstract and download

Schiff, N.D., and Posner, J.B. (2007) Another "awakenings." Annals of Neurology 62, 5-7.
Download this editorial from Annals of Neurology

Schiff, N.D., and Fins, J.J. (2007) Disorders of consciousness. Mayo Clinic Proceedings 82, 250-253.
Download this letter to the Editor from Mayo Clinic Proceedings

Fins, J.J., and Schiff, N.D. (2006) Shades of gray: new insights into the vegetative state. Hastings Center Reports 36, 8.

Voss, H.U., Ulug, A.M., Dyke, J.P., Watts, R., Kobylarz, E.J., McCandliss, B.D., Heier, L.A., Beattie, B.J., Hamacher, K.A., Vallabhajosula, S., Goldsmith, S.J., Ballon, D., Giacino, J.T., and Schiff, N.D. (2006) Possible axonal regrowth in late recovery from the minimally conscious state. Journal of Clinical Investigation 116, 2005-2011.
Abstract, download, and commentary

Shirvalkar, P., Seth, M., Schiff, N.D., and Herrera, D.G. (2006) Cognitive enhancement with central thalamic electrical stimulation. Proc. Natl. Acad. Sci. USA 103, 17007-17012.
Abstract and download

Schiff, N.D. (2006) Measurements and models of cerebral function in the severely injured brain. Journal of Neurotrauma 23, 1436-1449.
Abstract and download

Schiff, N.D. (2006) Multimodal neuroimaging approaches to disorders of consciousness. Journal of Head Trauma Rehabilitation 21, 388-397.
Abstract and download

Laureys, S., Giacino, J.T., Schiff, N.D., Schabusa, M., and Owen, A.M. (2006) How should functional imaging of patients with disorders of consciousness contribute to their clinical rehabilitation needs? Current Opinion in Neurology 19, 520–527.
Abstract and download

Schiff, N.D. (2005) Modeling the minimally conscious state: measurements of brain function and therapeutic possibilities. Progress in Brain Research, Vol. 150, chapter 33. pp. 473-493. Ed: S. E. Laureys. Elsevier.
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Schiff, N.D., Rodriguez-Moreno, D., Kamal, A., Kim, K.H., Giacino, J.T., Plum, F., and Hirsch, J. (2005) fMRI reveals large-scale network activation in minimally conscious patients. Neurology 64, 514-523.
Abstract and download

Kobylarz, E.J., and Schiff, N.D. (2005) Neurophysiological correlates of persistent vegetative and minimally conscious states. Neuropsychol. Rehabil. 15, 323-332.
Abstract amd download

Fins, J.J., and Schiff, N.D. (2005) The afterlife of Terri Schiavo. Hastings Cent Rep. 35, 8.

Laureys, S., Owen, A.M., and Schiff, N.D. (2004) Brain function in coma, vegetative state, and related disorders. Lancet Neurol. 3, 537-546.
Abstract and download

Kobylarz, E.J., and Schiff, N.D. (2004) Functional imaging of severely brain-injured patients: progress, challenges, and limitations. Arch. Neurol. 61, 1357-1360.
Abstract, editorial perspective, and download

Purpura, K.P., Kalik, S., and Schiff, N.D. (2003) Analysis of perisaccadic field potentials in the occipitotemporal pathway during active vision. J. Neurophysiol. 90, 3455-3478.
Abstract and download

Plum, F. and Schiff, N.D. (2003) Disorders of Consciousness. In L. Nadel (Ed.), Encyclopedia of Cognitive Science, Macmillan: London.
Summary and download

Schiff, N.D., Ribary, U., Moreno-Rodriguez, D., Beattie, B., Kronberg, E., Blasberg, R., Giacino, J., McCagg, C., Fins, J., Llinas, R. and Plum, F. (2002) Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain. Brain 125, 1210-1234
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Schiff, N.D and Purpura, K.P. (2002) Towards a neurophysiological foundation for cognitive neuromodulation through deep brain stimulation. Thalamus and Related Systems 2, 55-69.
Abstract and download

Schiff, N.D. and Plum, F. (2002) Possible relationships of anesthetic coma and pathological disorders of consciousness. Contemporary Clinical Neuroscience: Neural Mechanisms of Anesthesia Edited by Josph F. Antognini et al. Humana Press.
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Schiff, N.D., Plum, F., and Rezai, A.R. (2002) Developing prosthetics to treat conitive disabilities resulting from acquired brain injuries. Neurological Research 24, 116-124.
Abstract and download

Repucci, M.A., Schiff, N.D., and Victor, J.D. (2001) General strategy for hierarchical decomposition of multivariate time series: implications for temporal lobe seizures. Annals of Biomedical Engineering 29, 1135-1149.
Abstract, downloads, and access to software

Schiff, N.D., and Plum, F. (2000) The role of arousal and "gating" systems in the neurology of impaired consciousness. Journal of Clinical Neurophysiology 17, 438-452.
Abstract and download

Davey, M.P., Victor, J.D., and Schiff, N.D. (2000) Power spectra and coherence in the EEG of a vegetative patient with severe asymmetric brain damage. Clinical Neurophysiology 111, 1949-1954.
Abstract, key figures, and download

Schiff, N.D., Rezai, A.R., Plum, F. (2000) A neuromodulation strategy for rational therapy of complex brain injury states. Neurol. Res. 22, 267-272.
Abstract and download

Fins, J.J., and Schiff, N.D. (2000) Diagnosis and treatment of traumatic brain injury. Journal of the American Medical Association 283, 2392.
Abstract and download (with reply)

Schiff, N.D. (1999) Commentary: neurobiology, suffering, and unconscious brain states. Journal of Pain and Symptom Management 17, 303-304.
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Schiff, N.D., Purpura, K.P., and Victor, J.D. (1999) Gating of local network signals appears as stimulus-dependent activity envelopes in striate cortex. J. Neurophysiol. 82, 2182-2196.
Abstract, key figure, and downloads

Schiff, N.D., and Pulver, M. (1999) Does vestibular stimulation activate thalamocortical mechanisms that reintegrate impaired cortical regions? Proc. R. Soc. Lond. B266, 421-423.
Abstract and download

Schiff, N.D., and Plum, F. (1999) Cortical function in the persistent vegetative state. Trends in Cognitive Sciences 3, 43-44.
Abstract and download

Schiff, N.D., Labar, D.R., and Victor, J.D. (1999) Common dynamics in temporal lobe seizures and absence seizures. Neuroscience 91, 417-428.
Abstract and key figure

Schiff, N.D., Ribary, U., Plum, F., and Llinas, R. (1999) Words without mind. Journal of Cognitive Neuroscience 11, 650-656.
Abstract

Plum, F., Schiff, N., Ribary, U., and Llinas, R. (1998) Coordinated expression in chronically unconscious persons. Phil. Trans. R. Soc. Lond. B353, 1929-1933.
Abstract and download

Purpura, K.P., and Schiff, N.D. (1997) The thalamic intralaminar nuclei: A role in visual awareness. The Neuroscientist 3, 8-15.
Abstract and download

Schiff, N.D., Moore, D.F., and Winterkorn, J.M. (1996) Predominant downgaze ophthalmoparesis in anti-Hu encephalomyelitis. J. Neuroophthalmol. 16, 44-48.

Schiff, N.D., Victor, J.D., Canel, A., and Labar, D.R. (1995) Characteristic nonlinearities of the 3/second ictal EEG identified by nonlinear autoregressive analysis. Biological Cybernetics 72, 519-526.
Abstract, download, and key figure

Schiff, N.D., Victor, J.D., and Canel, A. (1995) Nonlinear autoregressive analysis of the 3/second ictal EEG: implications for underlying dynamics. Biological Cybernetics 72, 527-532.
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